منابع مشابه
Distinct Regions of the Mouse Cyclin A1 Gene, Ccna1, Confer Male Germ-Cell Specific Expression and Enhancer Function Expression of Ccna1 Reporter Genes in Mice cyclin, spermatogenesis, meiosis, gene regulation, testis
1 The gene encoding mouse cyclin A1, Ccna1, is expressed at highest levels in late 2 pachytene-diplotene spermatocytes, where it is required for meiotic cell division. To 3 begin to understand the mechanisms responsible for its highly restricted pattern of 4 expression, transgenic mouse lines carrying constructs consisting of the cyclin A1 5 regulatory region fused with the reporter gene lacZ w...
متن کاملCyclin A1 Is Expressed in Mouse Ovary
Cyclin A1 belongs to the type-A cyclins and participates in cell cycle regulation. Since its discovery, cyclin A1 has been shown mostly in testis. It plays important roles in spermatogenesis. However, there were also reports on ovary expression of cyclin A1. Therefore, we intended to revisit the expression of cyclin A1 in mouse ovary. Our study showed that cyclin A1 was expressed at the mRNA le...
متن کاملAnalysis of the genetic interactions between Cyclin A1, Atm and p53 during spermatogenesis.
AIM To analyze the functional interactions of Cyclin with p53 and Atm in spermatogenesis and DNA double-strand break repair. METHODS Two lines of double knockout mice were generated. Spermatogenesis and double strand break repair mechanisms were analyzed in Cyclin A1 (Ccna1); p53- and Ccna1; Atm-double knockout mice. RESULTS The block in spermatogenesis observed in Cyclin A1-/- (Ccna1-/-) t...
متن کاملCyclin A1 regulates WT1 expression in acute myeloid leukemia cells.
Cyclin A1 is a cell cycle protein that is expressed in testes, brain and CD34-positive hematopoietic progenitor cells. Cyclin A1 is overexpressed in a variety of myeloid leukemic cell lines and in myeloid leukemic blasts. Transgenic cyclin A1 overexpressing mice develop acute myeloid leukemia with low frequency. In this study, we looked for putative target genes of cyclin A1 in hematopoietic ce...
متن کاملThe Six1 homeoprotein stimulates tumorigenesis by reactivation of cyclin A1.
Homeobox genes constitute a large family of transcription factors that are essential during normal development and are often dysregulated in cancer. However, the molecular mechanisms by which homeobox genes influence cancer remain largely unknown. Here we show that the tissue-restricted cyclin A1 is a transcriptional target of the Six1 homeoprotein. Both genes are expressed in the embryonic but...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2012
ISSN: 1768-3262
DOI: 10.4267/2042/48223